Bone morphogenetic protein signaling regulates skin inflammation via modulating dendritic cell function

نویسندگان

چکیده

BackgroundBone morphogenetic proteins (BMPs) are members of the TGF-β family that signal via BMP receptor (BMPR) signaling cascade, distinct from canonical signaling. downstream is strongly induced within epidermal keratinocytes in cutaneous psoriatic lesions, and BMP7 instructs monocytic cells to acquire characteristics psoriasis-associated Langerhans dendritic (DCs). Regulatory T (Treg)-cell numbers increase during skin inflammation were recently shown limit inflammation. However, factors mediating Treg-cell accumulation currently remain unknown.ObjectiveWe sought investigate role psoriasis.MethodsThe following methods used: immunohistology patients healthy controls; ex vivo models generation presence or absence cells; analysis versus DCs Treg modeling mice lacking BMPR type 1a CD11c+ cells.ResultsWe here demonstrated a positive correlation between expression lesions show unlike skin, portion inflammation-associated exhibit constitutive-active We further found licenses cell/DC gain an enhanced capacity promote BMPR-mediated CD25 induction this effect associated with reduced inflammation.ConclusionsPsoriatic marked by constitutive high BMP7/BMPR keratinocytes, which inflammatory Treg-cell–stimulatory activity. Locally secreted can directly through cascade. Bone unknown. psoriasis. The cells. Psoriatic

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ژورنال

عنوان ژورنال: The Journal of Allergy and Clinical Immunology

سال: 2021

ISSN: ['1097-6825', '0091-6749', '1085-8725']

DOI: https://doi.org/10.1016/j.jaci.2020.09.038